Copper Toxicity/Chronic Active Hepatitis
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چکیده
The trace mineral Copper (Cu) is incorporated into several enzymes which catalyze important reactions in the body. Cu is mainly stored in the liver, but is also found in the skeletal system (bone marrow) as well as in muscle, brain and spleen tissue. While unavailable dietary Cu is excreted in the feces, via bile, approximately 40-60% of dietary (ingested) Cu is absorbed into the blood by the mucosa of the small intestine. The serum proteins albumin and transcuprein then transport Cu in the blood to the liver, which is the site of synthesis of the ironcontaining protein ceruloplasmin (CEP). CEP transports Cu to target tissues in the body, then returns to the liver. In the liver, CEP is degraded, resulting in Cu being lost in bile salts, which is a main route of excretion. Blockage of the bile ducts will lead to an accumulation of copper in the liver tissue. (Class notes, ANSC 604, Spring 1997).
منابع مشابه
Western blot analysis in patients with hypocaeruloplasminaemia.
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